Tags: Novartis Zelnorm FDA IBS Cardiovascular Adverse Events Constipation
Novartis Pharmaceuticals has agreed to stop selling Zelnorm because of safety concerns. Zelnorm (tegaserod maleate) had been approved to treat certain patients with irritable bowel syndrome and chronic constipation. Zelnorm was taken off the market because a new analysis of 29 studies showed that...
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o Both colonic inflammation and small bowel inflammation have been discovered in a subset of patients with irritable bowel syndrome versus controls.
o A higher prevalence of physical and sexual abuse has been demonstrated in patients with irritable bowel syndrome.
o Enhanced perception of normal motility and visceral pain characterizes.